منابع مشابه
Cardioprotection by remote ischaemic preconditioning.
Perioperative myocardial infarction is a leading cause of morbidity and mortality after major non-cardiac surgery. Pharmacological agents such as beta-blockers may reduce the risk but are associated with side-effects and may be contra-indicated in some patients. Basic scientific experiments and preliminary clinical trials in humans suggest that remote ischaemic preconditioning (RIPC), where bri...
متن کاملRemote ischaemic preconditioning: closer to the mechanism?
Brief periods of ischaemia followed by reperfusion of one tissue such as skeletal muscle can confer subsequent protection against ischaemia-induced injury in other organs such as the heart. Substantial evidence of this effect has been accrued in experimental animal models. However, the translation of this phenomenon to its use as a therapy in ischaemic disease has been largely disappointing wit...
متن کاملIschaemic preconditioning: present position and future directions.
Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concern...
متن کاملIschaemic preconditioning of the liver before transplantation
122 The protection of the myocardium by ischaemic preconditioning (IP) has been well established. Recently there have been several studies indicating that a similar process exists in the liver. The exact mechanism of IP has not yet been clarified. There is ample evidence that toxic oxygen radicals play the crucial role in preservation-reperfusion injury. It is therefore likely that free radical...
متن کاملNitric oxide, nitrates and ischaemic preconditioning.
1. Introduction model produced significant protection against myocardial cell death. There appears to be a bimodal distribution of In 1986 Furchgott first suggested that endothelial-de-protection with an initial more powerful but short-lived rived relaxing factor might be nitric oxide (NO) [1]. Since phase existing between 1 and 3 h ('Early Preconditioning') then the remarkable role of nitric o...
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ژورنال
عنوان ژورنال: BMJ
سال: 1994
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.308.6920.1